Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (33): 6127-6131.doi: 10.3969/j.issn.2095-4344.2012.33.010

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Effect of resistance training on p53 and bax gene expression in the skeletal muscle of aging mice

Wang Li-feng1, Li Hai-peng2, Lu Jian1   

  1. 1Department of Physical Education and Health, East China Normal University, Shanghai 200241, China;
    2School of Human Sports Science, Shanghai University of Sport, Shanghai 200081, China
  • Received:2012-06-04 Revised:2012-07-17 Online:2012-08-12 Published:2012-08-12
  • About author:Wang Li-feng☆, Studying for doctorate, Department of Physical Education and Health, East China Normal University, Shanghai 200241, China wanglifeng1982@126.com

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Abstract:

BACKGROUND: Resistance training can alleviate muscle attenuation and weaken the apoptosis of skeletal muscle cells.
OBJECTIVE: To observe the effects of aging and resistance training on the expression of p53 and bax genes in the skeletal muscle of SAMP-8 mice.
METHODS: SAMP-8 mice aged 3 months and 6 months were selected to undergo 8-week ladder movement (three times per week). Another mice at the same age without movement served as controls.
RESULTS AND CONCLUSION: Real-time PCR showed that p53 and bax mRNA expression increased significantly in the skeletal muscle fibers of 3-month-old mice than 6-month-old mice (P < 0.05). However, compared with those at the same age, p53 and bax mRNA expression in the skeletal muscle fibers decreased significantly in mice undergoing ladder movements (P < 0.05). These findings indicate that resistance movements can suppress p53 and bax gene expression in the skeletal muscle of aging mice.

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