Abstract:

BACKGROUND: The number of lung transplantation cases in China is few, and the reason why the survival time after lung transplantation is shorter than that after other organ transplantation is unclear.
OBJECTIVE: To estimate the influence factors of long-term survival after lung transplantation.
METHODS: A retrospective analysis on the clinical data of 61 cases of patients with end-stage lung disease was preformed after lung transplantation. The patients were divided into two groups according to the survival time of follow-up. The survival time of observation group (n=29) was over 3 years and the control group (n=32) was less than 1 year. The general characteristics of patients, surgical (single or double lung transplantation), pulmonary artery pressure, application of extracorporeal membrane oxygenation were compared by muhivariable logistic regression model.
RESULTS AND CONCLUSION: Statistics analysis confirmed that age (≥ 50 years), pulmonary hypertension before lung transplantation, acute rejection and severe pulmonary infection are the independent risk factors that could influence the long-term survival of patients after lung transplantation. As for end-stage lung disease treated with lung transplantation, the selection of favorable patients, reducing mean pulmonary artery pressure preoperatively, use of extracorporeal membrane oxygenation during transplantation, precaution of pulmonary infection after transplantation and strict immunosuppressive therapy are the important measures to prolong the survival time of the patients.