Abstract:

BACKGROUND: The delayed recovery of renal function after renal transplantation is one form of acute renal failure, mostly resulting from ischemia-reperfusion injury and rejection, blood purification has been widely utilized as a basic treatment approach of delayed recovery of renal graft function.
OBJECTIVE: To compare the efficacy of different dialysis methods on delayed recovery of renal function, to select the appropriate dialysis methods and to improve transplantation efficacy.
METHODS: A total of 56 patients with delayed recovery of renal graft function after transplantation were respectively treated with hemodialysis (n=25), hemodialysis and filtration (n=21) and peritoneal dialysis (n=10), to observe blood pressure, cytokines levels and efficacy before and after different dialysis treatments.
RESULTS AND CONCLUSION: Totally 56 patients with delayed graft function survived with renal graft. Compared with hemodialysis and peritoneal dialysis groups, the incidences of hypotension and postoperative infection were lower in hemodialysis and filtration group (P < 0.01), and the recovery time of renal function was shorter (P < 0.01). There was no significant difference in the incidences of hypotension and the recovery time of renal function between hemodialysis group and peritoneal dialysis group. The incidence of postoperative infection in the peritoneal dialysis group was higher than that in hemodialysis group (P < 0.01). Levels of tumor necrosis factor α, interleukin-1β and interleukin-6 after hemodialysis and filtration was significantly decreased compared with pre-dialysis levels (P < 0.01), while no significant difference was found before and after the hemodialysis alone (P > 0.05). The present study shows that, hemodialysis and filtration can stabilize the hemodynamics, effectively reduce inflammation, and shorten time for renal function recovery in patients with delayed graft function after transplantation.