Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (29): 5345-5349.doi: 10.3969/j.issn.2095-4344.2012.30.024

Previous Articles     Next Articles

Intervertebral fusion cage made by poly-amino acid/hydroxyapatite composites in a goat cervical spine model

Peng Lei, Quan Zheng-xue, Tan Chao, Ou Yun-sheng, Tang Ke   

  1. Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2012-03-20 Revised:2012-04-18 Online:2012-07-15 Published:2012-07-15
  • Contact: Quan Zheng-xue, Chief physician, Professor, Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China quanzx18@126.com
  • About author:Peng Lei★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China penglei828@ 126.com

PDF

328

Abstract:

BACKGROUND: Poly-amino acid/nano-hydroxyapatite composite material has been proved to have a good bio-security.
OBJECTIVE: To evaluate the fusion effect of poly-amino acid/nano-hydroxyapatite interbody cage in a goat cervical spine model.
METHODS: Sixteen adult male goats underwent C3-4 discectomy and intervertebral fusion with poly-amino acid/nano-hydroxyapatite interbody cage (experimental group, n=8) or autogenous iliac (control group, n=8). X-ray was taken at 2, 4, 8 and 12 weeks after surgery to measure the intervertebral height. CT scanning and histology examination were performed at 4 and 12 weeks after surgery.
RESULTS AND CONCLUSION: Referring to radiography and histomorphology findings, the goats with poly-amino acid/nano-hydroxyapatite cage or autograft all showed fine fusion at 12 weeks, without significant difference. The intervertebral fusion cage of poly-amino acid/nano-hydroxyapatite has good initial stability and fusion which may be an ideal interbody fusion appliance.

CLC Number: