Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5297-5303.doi: 10.3969/j.issn.2095-4344.2012.28.034

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Research progress of heart type fat binding protein and its application in cardiac surgery

Wang Shi-xiong1, Li Ning-yin1, Gao Bing-ren2   

  1. 1Second Clinical Medical School of Lanzhou University, Lanzhou 730000, Gansu Province, China;
    2Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
  • Received:2012-02-14 Revised:2012-04-26 Online:2012-07-08 Published:2012-07-08
  • Contact: Gao Bing-ren, Chief physician, Professor, Doctoral supervisor, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China bingrengao@sina.com
  • About author:Wang Shi-xiong★, Studying for master’s degree, Second Clinical Medical School of Lanzhou University, Lanzhou 730000, Gansu Province, China wangshi0815@163.com

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Abstract:

BACKGROUND: Heart-type fatty-binding protein is one of the most abundant proteins in the cytoplasm of myocardial cells, which is a marker protein for myocardial injury.
OBJECTIVE: To summarize the biology structure and function, metabolism dynamics of heart-type fatty binding protein, and their progress in clinical research and application in cardiac surgery.
METHODS: A search of PubMed and VIP databases (1983-01/2010-12) was performed by the first author for the literature of the biological structure and function of heart-type fatty-binding proteins and their application in cardiac surgery as well as other clinical applications. The keywords were “creatine kinase isoenzyme, heart fatty acid-binding protein, acute myocardial infarction, coronary artery bypass grafting” in English and in Chinese, respectivley. Unrelated articles or repetitive articles were excluded, and finally 62 articles were included in result analysis.
RESULTS AND CONCLUSION: Heart-type fatty-binding protein is a soluble protein with a low molecular weight, more specific in myocardial cytoplasm, and no or a little in normal plasma, which can quick release after myocardial damage. Heart-type fatty-binding protein has a good diagnostic value for perioperative myocardial injury after on-pump coronary artery bypass, and it is a potential indicator in the rapid assessment of myocardial injury induced by cardiopulmonary bypass valve replacement surgery as soon as possible. Elevated levels of heart-type fatty-binding proteins can be earlier to judge the severity of myocardial injury and to determine the degree of impaired cardiac function and heart-related complications.

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