Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5227-5231.doi: 10.3969/j.issn.2095-4344.2012.28.020

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Improved effect of acupuncture on insulin expression of islet beta cells in type 2 diabetes rats

Sun Zhi1, Ma Li1, Han Hai-rong2, Zhang Zuo-ji2, Kong Ling-bin2   

  1. 1Laboratory of Integrated Acupuncture and Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China;
    2Jining Medical College, Jining 274300, Shandong Province, China
  • Received:2011-12-09 Revised:2011-12-27 Online:2012-07-08 Published:2012-07-08
  • About author:Sun Zhi,☆ Doctor, Chief physician, Professor, Laboratory of Integrated Acupuncture and Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China sunzhi63@163.com

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Abstract:

BACKGROUND: Acupuncture for type 2 diabetes has obtained good clinical effects.
OBJECTIVE: To observe the effect of acupuncture on insulin expression of islet beta cells in type 2 diabetes rats.
METHODS: The diabetes model rats were randomly divided into acupuncture, rosiglitazone, model and normal control groups. Acupoints of Zusanli, Neiting and Yishu were selected in the acupuncture group for needling. Rosiglitazone (0.2 mg/kg) were given intragastrically in the rosiglitazone group. Double distilled water (2 mL/kg) was given intragastrically in the model group once daily for 4 consecutive weeks.
RESULTS AND CONCLUSION: ① Blood glucose level of the acupuncture group was significantly lower than that of the model and rosiglitazone groups (P < 0.05). ② Blood lipid: Cholesterol and triglyceride of the acupuncture group were significantly lower than those of the model group (P < 0.05), and high-density lipoprotein cholesterol of the acupuncture group was significantly higher than that of the model group (P < 0.01). The above three indicators between the acupuncture and rosiglitazone groups had no significant difference. ③ The insulin expression of islet beta cells in the acupuncture group was significantly higher than that of the model and rosiglitazone groups (P < 0.05). ④ Morphology of islet: Islet structure was incomplete and damaged, and the staining of insulin was poor in the model and rosiglitazone groups. Islet structure tended to be complete, and staining of insulin was visible in the acupuncture group. It is indicated that acupuncture can significantly increase the insulin expression and improve the function of islet beta cells in type 2 diabetes rats.

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