Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5191-5195.doi: 10.3969/j.issn.2095-4344.2012.28.013

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Effect of brain peptide in rat models of liver fibrosis

Xi Wen-na1, Sun Shui-lin1, Li Fang-chun2, Yao Xue-bing1, Zhang Wei1, Yi Zhen1, Ye Chang-gen1, Liu Cui-yun1   

  1. 1Department of Infectious Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China;
    2Department of Infectious Diseases, People’s Hospital of Fengcheng City, Fengcheng 331100, Jiangxi Province, China
  • Received:2011-12-08 Revised:2012-02-22 Online:2012-07-08 Published:2012-07-08
  • Contact: Sun Shui-lin, Professor, Chief physician, Department of Infectious Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China sunshuilin2280@126.com
  • About author:Xi Wen-na★, Master, Physician, Department of Infectious Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

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Abstract:

BACKGROUND: Brain peptide is a kind of peptide mixture extracted from animal brain tissues, containing nerve growth factors. In recent years, studies have shown that nerve growth factors are closely related to liver injury.
OBJECTIVE: To study the effect of brain peptide on liver fibrosis in rats.
METHODS: Liver fibrosis was induced in rats by subcutaneous injection of CCl4 in SD rats, and then rat models were randomly divided into fibrosis model group, brain peptide intervention group and control group. The samples were collected at 4 and 8 weeks. Automatic biochemical analyzer was used to detect serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin. Radioimmunoassay detection of liver fibrosis markers, hyaluronic acid, laminin, procollagen III, was performed. Liver tissue samples were detected by hematoxylin-eosin and reticular fiber staining.
RESULTS AND CONCLUSION: The rat liver fibrosis model was successfully established. Liver fibrosis was relieved significantly in the brain peptide intervention group than the fibrosis model group, but the extent of hepatic inflammation and fatty degeneration significantly increased. Brain peptide can effectually prevent CCl4-induced liver fibrosis, and the mechanism of preventing liver fibrosis may be related with nerve growth factors.

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