Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (28): 5181-5184.doi: 10.3969/j.issn.2095-4344.2012.28.011

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Effect of yohimbine, naloxone and their combination on analepsia from ketamine-induced anesthesia in mice

Chen Lin, Zhang Cai-li, Ju Yan-min, Zhou Zhen-lei   

  1. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China
  • Received:2012-01-15 Revised:2012-02-11 Online:2012-07-08 Published:2012-07-08
  • Contact: Zhou Zhen-lei, Doctor, Associate professor, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China
  • About author:Chen Lin, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China njauchenlin@163.com

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Abstract:

BACKGROUND: Yohimbine and naloxone are widely used as narcotic antagonists in clinic, especially against ketamine-induced anesthesia.
OBJECTIVE: To investigate the analeptic effects of yohimbine, naloxone and their combination on ketamine-induced anesthesia in mice.
METHODS: Forty Kunming mice were randomly assigned to four groups, and all mice were intraperitoneally administered with ketamine. One minute after loss of righting reflex, different groups were intraperitoneally injected with normal saline, yohimbine, naloxone, yohimbine+naloxone, respectively. The duration of loss righting reflex (sleeping time) was recorded.
RESULTS AND CONCLUSION: Compared with the normal saline group, the sleeping time in the yohimbine, naloxone and yohimbine+naloxone groups was obviously decreased. In addition, significant difference was also observed between the single treated and combined groups. Yohimbine, naloxone and their combination can efficaciously play an antagonistic role in the narcotism of ketamine.

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