Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (2): 220-222.doi: 10.3969/j.issn.1673-8225.2012.02.006

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Effects of polygonatum polysaccharide on the expression of interleukin-1 and 6 in rats withosteoporotic fracture

Zeng Gao-feng1, Zhang Zhi-yong1, Lu Li1, Xiao De-qiang1, Zong Shao-hui1, Xiong Chun-xiang3, Zhao Yu-xi3
   

  1. 1School of PublicHealth, GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China;
    2Departmentof Spine Surgery,First AffiliatedHospital of GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China;
    3PostgraduateCollege, GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China
  • Received:2011-07-04 Revised:2011-07-04 Online:2012-01-08 Published:2012-01-08
  • Contact: Zhang Zhi-yong,Doctor, Professor,School of PublicHealth, GuangxiMedical University,Nanning 530021,Guangxi ZhuangAutonomous Region,China rpazz@163.com
  • About author:Zeng Gao-feng☆,Doctor, Associateprofessor, School ofPublic Health,Guangxi MedicalUniversity, Nanning530021, GuangxiZhuang AutonomousRegion, China xiaohui3008@126.com
  • Supported by:

    Scientific ResearchFoundation ofEducationDepartment ofGuangxi ZhuangAutonomous Region,No.302204*; PublicHealth andPreventive MedicinePostdoctoralFoundation ofGuangxi MedicalUniversity, No.308084*

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Abstract:

BACKGROUND: Osteoporotic fracture is an osteoporotic complication caused by reduced estrogen and can be effectivelycorrected by estrogen supplementation.
OBJECTIVE: To investigate the effects of polygonatum polysaccharide (PSP) on cytokines in osteoporotic fracture rats.
METHODS: Sprague-Dawley rats, aged 6 weeks old, were established into osteoporosis models by ovariectomy. After 90 days,the tibia was cut off to create models of osteoporotic fracture. At 1 week after osteoporotic fracture, rats were intragastricallyadministered 400, 200, 100 mg/kg PSP and intramuscularly administered estradiol.
RESULTS AND CONCLUSION: Compared with common fracture rats, serum level of interleukin 1, 6 was increased inosteoporotic fracture rats. After intervention with 400 mg/kg PSP or estradiol, serum level of interleukin 1, 6 in osteoporotic fracturerats was significantly decreased (P < 0.05), but 200 and 100 mg/kg PSP did not affect

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