Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (2): 211-214.doi: 10.3969/j.issn.1673-8225.2012.02.004

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Role of bone morphogenetic protein-7 in the distraction osteogenesis of rat mid-palatal suture

Li Wei1, Li Kun2, Wang Pei-jun1, Han Jing-ying1   

  1. 1Department ofOrthodontics,2Research Division,the Second AffiliatedHospital of HarbinMedical University,Harbin 150086,HeilongjiangProvince, China
  • Received:2011-11-01 Revised:2011-12-06 Online:2012-01-08 Published:2012-01-08
  • Contact: Han Jing-ying,Studying fordoctorate,Department ofOrthodontics, theSecond AffiliatedHospital of HarbinMedical University,Harbin 150086,HeilongjiangProvince, Chinajingying5787@163.com
  • About author:Li Wei★, Studying formaster’s degree,Physician,Department ofOrthodontics, theSecond AffiliatedHospital of HarbinMedical University,Harbin 150086,HeilongjiangProvince, China 15904611995@163.com
  • Supported by:


    theNatural ScienceFoundation ofHeilongjiangProvince, No.D20965*; the YouthFoundation for Technological
    Innovation of theMunicipal Committeeof Science andTechnology, No.2010RFQXS113*

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Abstract:

BACKGROUND: Experiments have confirmed that bone morphogenetic protein-7 can induce bone and cartilage formation; it canalso promote bone formation in the process of distraction osteogenesis.
OBJECTIVE: To explore the role of bone morphogenetic protein-7 in the suture distraction osteogenesis of rat mid-palatal suture and to detect the changes of bone morphogenetic protein-7 under the mechanical expansion force.
METHODS: Expansionary force was applied on rats using a self-made expansing arch spring for binoculus to construct maxillary expansion rat model. Rat mid-palatal sutures were randomly collected on 1, 3, 5, 7, 9, 12 and 14 days after model construction;real-time PCR was performed to detect the changing regularities of the target genes.
RESULTS AND CONCLUSION: The expression of the bone morphogenetic protein-7 mRNA in the rat mid-palatal suturesincreased gradually on 3, 9, 12 and 14 days after model construction (P < 0.05). These findings demonstrate that bonemorphogenetic protein-7 mRNA expression is significantly increased in the distraction osteogenesis process of rat mid-palatalsutures under the stimulus of mechanical force.

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