Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (2): 191-200.doi: 10.3969/j.issn.1673-8225.2012.02.001

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In vitro culture of osteoblasts: A bibliometric analysis based on Science Citation Index, NationalInstitutes of Health and Derwent Innovations Index from 2008 to 2010

Rui Gang1, Jin Xu-hong2, Guo Yuan-li1, Hu Bao-shan1   

  1. 1Department ofOrthopaedics, 2Department ofLaboratory Medicine,First AffiliatedHospital of XiamenUniversity, Xiamen361003, FujianProvince, China
  • Received:2011-11-10 Revised:2011-12-07 Online:2012-01-08 Published:2012-01-08
  • About author:Rui Gang☆, Doctor,Chief physician,Master’s supervisor,Department ofOrthopaedics, FirstAffiliated Hospital ofXiamen University,Xiamen 361003,Fujian Province,China reigang@yahoo.com.cn

Abstract:

BACKGROUND: Osteoblasts play an important role in the regulation of bone metabolism. The bone formation and loss areaffected by osteoblast differentiation and apoptosis.
OBJECTIVE: To identify the global research trends in in vitro culture of osteoblasts from 2008 to 2010 via a bibliometric analysisof Science Citation Index (SCI), National Institutes of Health (NIH) and Derwent Innovations Index.
DESIGN: A bibliometric study.

DATA RETRIEVAL:We performed a bibliometric analysis based on the SCI, NIH and Derwent Innovations Index for dataregarding in vitro culture of osteoblasts from 2008 to 2010. The data were downloaded on October 18, 2011.
SELECTION CRITERIA: ①Articles closely related to in vitro culture of osteoblasts, ②with funding item for in vitro culture ofosteoblasts, and ③with patents related to in vitro culture of osteoblasts were included. Exclusive criteria: ①document types suchas meeting abstracts, reviews, proceedings papers, notes, and letters; ②non-published articles.
MAIN OUTCOME MEASUREMENTS:①Types of documents; ②number of author outputs; ③distribution of output in subjectcategories; ④publication distribution of countries and institutes; ⑤distribution of output in journals; ⑥distribution of citations;⑦funding items; ⑧patents.
RESULTS: ①During 2008 to 2010, 2 612 papers focusing on in vitro culture of osteoblasts were added to the SCI. Articles werethe most frequently used document type. ②The result showed that the amount of literature was annually increased, and therewere 22 core institutes, 12 core journals and 13 classical references. The Journal of Biomedical Materials Research Part Apublished most articles addressing in vitro culture of osteoblasts, followed by Biomaterials and Bone. ③Totally 1 443 articles(60.3%) obtained funding supports from 2 090 funding agencies. ④A total of 398 international patents were searched. All resultsdemonstrated that the topics inosteoblast research are being published around the world.
CONCLUSION: From the analysis of research trends, we put forward suggestions for medical staffs who are currentlyundertaking studies and for those who will be researching and studying in vitro culture of osteoblasts.

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