Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (8): 1402-1404.doi: 10.3969/j.issn.1673-8225.2011.08.017

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Preparation of oryzanol-chitosan microcapsules

Gu Jie-bo, Fan Chun-lei, Hu Lin-feng, Li Hao-rong   

  1. College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou  310053, Zhejiang Province, China
  • Received:2010-11-23 Revised:2010-12-20 Online:2011-02-19 Published:2011-02-19
  • Contact: Fan Chun-lei, Master, College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang Province, China snow@zjtcm.net
  • About author:Gu Jie-bo, College of Life Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang Province, China bbxmforever@163.com
  • Supported by:

    Science and Technology Planning Project of Zhejiang Province, China, No. 2006C33006*

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Abstract:

BACKGROUND: Chitosan has a good biocompatibility and biodegradability; it can be used as excellent drug controlled release and targeting vector, mucosal absorbent, absorption enhancers. However, the oryzanol sustained-release formulation as well as related literature has not been reported on the market.
OBJECTIVE: To investigate the preparation of oryzanol-chitosan microcapsules.
METHODS: Oryzanol-chitosan microcapsules were prepared by using of self-made centrifugal sieve granulator under the guidance of coagulation method, and the drug loading and encapsulation efficiency were investigated.
RESULTS AND CONCLUSION: The microcapsules were in uniform size, good finish and shape, drug loading of 47.68%, entrapment efficiency of 76.45%. The coagulation method is simple, stable and good reproducible. The results show that it is practicable to encapsulate oryzanol by using of natural polymer polysaccharide chitosan. The oryzanol-chitosan microcapsules have further development and application value.

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