Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1227-1231.doi: 10.3969/j.issn.1673-8225.2011.07.019

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Protective effect of zeaxanthin on lipid peroxidation injure of blood vessel induced by high lipid in quail model

Li Hong-yan1, Li Li-ya2, Nong Lin-ling2, Hu Chun-ping1, Li Lei1, Lai Zhen-hong1, Zhou Zhi-shun1, Li Xun1   

  1. 1Institute of Biotechnology , 2School of Basic Medical Science of Guilin Medical University, Guilin   541004, Guangxi Zhuang Autonomous Region, China
  • Received:2010-09-07 Revised:2010-11-08 Online:2011-02-12 Published:2011-02-12
  • Contact: Li Hong-yan, Master, Lecturer, Institute of Biotechnology, Guilin Medical University, Guilin 541004, Guangxi Zhuang Autonomous Region, China hong_yanli@sina.cn
  • About author:Li Hong-yan★, Master, Lecturer, Institute of Biotechnology, Guilin Medical University, Guilin 541004, Guangxi Zhuang Autonomous Region, China
  • Supported by:

     the Key Disciplines of Pharmaceutical Biotechnology Fund, Guilin Medical University*

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Abstract:

BACKGROUND: Most synthetic long-term use of antioxidant drugs have certain side effects, zeaxanthin as a natural medicine has its unique physiological effects.
OBJECTIVE: To observe the dose-effect relationship of zeaxanthin on lipid peroxidation injure of blood vessel induced by high lipid in quail hyperlipidmia model.
METHODS: Quail hyperipidmia models were established. A total of 40 quails were randomly divided into four groups: control group, model group, zeaxanthin low-dose group and zeaxanthin high-dose group. Seven weeks after gavage using zeaxanthin with 30, 60mg/kg, fasting plasma was harvested to determine serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) level, serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and activity of inducible nitric oxide synthase (iNOS). The TC and TG levels of liver tissue in each group were detected; aortic vascular pathological changes were observed with hematoxylin - eosin staining.
RESULTS AND CONCLUSION: Compared with model group,high-dose group of zeaxanthin of the concentration of serum TG, TC, and LDL-C were significantly decreased, while the concentration of serum HDL-C were significantly increased. The synthesis of liver total TG and TC was also strongly inhibited. The activity of glutathione peroxidase and supervxide dismutase were significantly increased, however, the activity of inducible nitric oxide synthase was decreased and MDA level was reduced. Zeaxanthin has a good lipid-lowing effect, and plays a notable inhibitory role in lipid peroxidation injure of blood vessel induced by high lipid. In addition, high-dose of zeaxanthin has better effects than low-dose.

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