Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1124-1126.doi: 10.3969/j.issn.1673-8225.2011.07.018

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Correlation between soluble receptor for advanced glycation end products levels in synovial fluid and disease severity of knee osteoarthritis 

Li Jian-hua1,2, Gao Wei2, Qiu Nan-hai2   

  1. 1Tianjin Medical University, Tianjin  300050, China
    2Department of Orthopedics, Haihe Hospital, Tianjin  300350, China
  • Received:2010-11-19 Revised:2011-01-05 Online:2011-02-12 Published:2011-02-12
  • About author:Li Jian-hua★, Studying for master’s degree, Physician, Tianjin Medical University, Tianjin 300050, China; Department of Orthopedics, Haihe Hospital, Tianjin 300350, China lijianhuajianhua@163.com

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Abstract:

BACKGROUND: Studies have demonstrated that soluble receptor for advanced glycation end products (sRAGE) levels in synovial fluid might be negatively associated with disease severity of knee osteoarthritis (OA).
OBJECTIVE: To determine the correlation between sRAGE levels in synovial fluid of OApatients and disease severity.
METHODS: A total of 46 OA patients and 14 healthy controls were enrolled. The OA was defined using the revised criteria of American Rheumatism Association for the classification of rheumatoid arthritis. The disease severity of OA was graded by Kellgren-Lawrence classification. sRAGE levels in synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA).
RESULTS AND CONCLUSION: sRAGE levels in synovial fluid were significantly lower in OA patients than in healthy controls (P < 0.01). sRAGE levels in synovial fluid were negatively associated with disease severity of OA (r=−0.587, P < 0.01). These results demonstrated that sRAGE levels might be associated with the severity and progression of knee OA.

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