Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (7): 1191-1194.doi: 10.3969/j.issn.1673-8225.2011.07.011

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Expression of vascular endothelial growth factor and hypoxia-inducible factor-1 alpha during scar mutation in rabbit ears

Zhang Gang1, Tan Jun2, Li Gao-feng2   

  1. 1Department of Burn and Plastic Surgery, Liuyang People’s Hospital, Liuyang  410300, Hunan Province, China
    2Department of Plastic and Laser Cosmetics, Hunan Provincial People’s Hospital, Changsha  410005, Hunan Province, China
  • Received:2010-08-23 Revised:2010-09-29 Online:2011-02-12 Published:2011-02-12
  • Contact: Zhang Gang, Master, Attending physician, Department of Burn and Plastic Surgery, Liuyang People’s Hospital, Liuyang 410300, Hunan Province, China zhanggang7802@126.com
  • About author:Zhang Gang★, Master, Attending physician, Department of Burn and Plastic Surgery, Liuyang People’s Hospital, Liuyang 410300, Hunan Province, China zhanggang7802@126.com

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Abstract:

BACKGROUND: Scar studies have cover histological, cellular and molecular levels nearly 20 years, but the mechanism of scar formation is not clarified. How to explore an ideal method for preventing and treating scar is an urgent and difficult task in both medical field and clinical application.
OBJECTIVE: To investigate molecular mechanism of scar formation by observing expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 α (HIF-1α) during scar mutation in rabbit ears.
METHODS: A rabbit ears scar animal model was prepared, normal skin and scars at 14, 30, 60 and 90 days were collected. Histomorphological changes of scars were observed by hematoxylin-eosin staining and the expression of VEGF and HIF-1α was detected by immunohistochemical method.
RESULTS AND CONCLUSION: Compared with other time points, the expression of VEGF and HIF-1α was greater at 14 days after operation, and gradually decreased with time prolonged and scar mature, which close to normal levels at 90 days after operation. The findings demonstrated that HIF-1α and VEGF play a regulation role in oxygen partial pressure changes of scar tissues.

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