Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 360-363.doi: 10.3969/j.issn.1673-8225.2011.02.042

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Associations between matrix metalloproteinase-9 polymorphism R279Q and coronary heart disease in Uighur population of Xinjiang 

Wang Lei, Ma Yi-tong, Xie Xiang, Yang Yi-ning, Fu Zhen-yan, Liu Fen, Li Xiao-Mei, Chen Bang-dang   

  1. Department of Cardiology, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
  • Received:2010-07-03 Revised:2010-08-05 Online:2011-01-08 Published:2011-01-08
  • Contact: Ma Yi-tong, Professor, Chief physician, Doctoral supervisor, Department of Cardiology, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China myt-xj@163.com
  • About author:Wang Lei★, Studying for master’s degree, Physician, Department of Cardiology, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China xjwanglei222@sina.com
  • Supported by:

    the Xinjiang Science and Technology Major Project, No. 200733146-3

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Abstract:

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in the development of atherosclerotic lesion. The potentially functional MMP-9 polymorphisms may contribute to the susceptibility of coronary heart disease (CHD).
OBJECTIVE: To investigate the association between matrix metalloproteinase-9 polymorphism (R279Q) and CHD in Uighur population of Xinjiang.
METHODS: A total of 362 patients with CHD and 413 control subjects were selected. Polymerase chain reaction and restriction fragment length polymorphism (RFLP-PCR) was used to detect the common R279Q polymorphism of the MMP-9 gene. The relationship between the polymorphism in the MMP-9 gene and the severity of coronary arterial stenosis was analyzed.
RESULTS AND CONCLUSION: The frequencies of RR, RQ and QQ were 34.3%, 42.8% and 22.9% in the CHD group while those were 37.8%, 43.3% and 18.9% in the control group. The RQ+QQ genotype frequency (65.7%, 62.2%) and Q-allele frequency (44.3%, 40.6%) in the CHD group and control group showed not statistically significant differences, respectively (x2=1.04, P=0.31; χ2=2.26, P=0.13). The frequencies of RQ and QQ genotypes of the R279Q polymorphism were not statistically different among CHD patients with one, two and three or more significantly diseased vessels (χ2=0.61,P=0.74). The findings suggest no significant association was found between R279Q polymorphism and CHD in Uighur population of Xinjiang.

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