Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 351-355.doi: 10.3969/j.issn.1673-8225.2011.02.040

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Role and mechanism of platelet-derived growth factor in cell proliferation and tissue repair  

Xie Ai-guo1, Liang Hong-wei2, Tan Qian3   

  1. 1Department of Burns and Plastic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing  210011, Jiangsu Province, China
    2Department of Plastic Surgery, Zhengzhou People’s Hospital, Zhengzhou  450003, Henan Province, China
    3Department of Plastic Surgery, Drum Tower Hospital, Medical College of Nanjing University, Nanjing  210008, Jiangsu Province, China
  • Received:2010-08-16 Revised:2010-10-23 Online:2011-01-08 Published:2011-01-08
  • About author:Xie Ai-guo★, Master, Physician, Department of Burns and Plastic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China dr.aigo@yahoo.com.cn
  • Supported by:

    the Science Development Foundation of Nanjing Medical University, No. 09NJMUM 025

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Abstract:

BACKGROUND: Cell proliferation and tissue repair is a complicated process, accompanied by participation of multiple growth factors, and these factors from a system in which they play their roles not in an independent, but interacting and inter-restricting manner. 
OBJECTIVE: To summarize the role and mechanism of platelet-derived growth factor (PDGF) in cell proliferation and tissue repair.
METHODS: PubMed, EMbase, Chinese Biomedical Literature Database, CNKI, CAJ were retrieved by computer with keywords of “platelet-derived growth factor, cell proliferation, tissue repair”. The language was limited for English and Chinese.
RESULTS AND CONCLUSION: PDGF is one of the major mitogens and is responsible for proliferation and migration of various cells. PDGF and its receptors located in multiple tissues and cells, which combined with receptors and play its role when the body suffered certain stimulation. Thus, plenty of studies showed that the expression of PDGF gene was increased in the period of surgery or damage repair. The biological characteristics of PDGF have been recognized primarily. The specific mechanism of repair is not clarified and many problems need to be explored in further study.

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