Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 343-346.doi: 10.3969/j.issn.1673-8225.2011.02.038

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Effect of Calcineurin transduction pathway on skeletal muscle remodeling

He Jie, Qi Zheng-tang, Ding Shu-zhe   

  1. College of Physical Education & Health, East China Normal University, Shanghai 200241, China
  • Received:2010-07-22 Revised:2010-08-17 Online:2011-01-08 Published:2011-01-08
  • Contact: Ding Shu-zhe, Professor, Doctoral supervisor, College of Physical Education & Health, East China Normal University, Shanghai 200241, China szding@tyxx.ecnu.edu.cn
  • About author:He Jie☆, Studying for doctorate, College of Physical Education & Health, East China Normal University, Shanghai 200241, China hejieapple@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30871212; Program for New Century Excellent Talents in University, No. 790013P8; Pujiang Plan Program of Shanghai, No. 44038470

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Abstract:

BACKGROUND: Skeletal muscle remodeling is an adaptive change of morphological structure and metabolic function to response to multiple stimuli. In the past years, the role of Calcineurin (CaN)/nuclear factor of activated T cells (NFAT) signaling has aroused increasing attention in skeletal muscle remodeling.
OBJECTIVE: To summarize and discuss the functions of CaN signaling transduction in metabolic remodeling from anaerobic metabolism to aerobic metabolism, myofiber type conversion, and skeletal muscle hypertrophy.
METHODS: A compute-based online search was performed by the first author ISI Web of knowledge database (1998/2010) with key words were “calcineurin, skeletal muscle, hypertrophy, NFAT, muscle fiber type” in English. The functions of CaN signaling transduction in metabolic remodeling were introduced from anaerobic metabolism to aerobic metabolism, myofiber type conversion, and skeletal muscle hypertrophy. 
RESULTS AND CONCLUSION: A total of 186 papers had been searched and 33 papers were chosen. The result shows that the activation of CaN/NFAT signaling contributes to the differentiation of myofiber type I and the improvement of aerobic metabolism and endurance, but not only CaN can improve the endurance. CaN/NFAT signaling transduction pathway may regulate skeletal muscle hypertrophy by the activation of utrophin A. Accordingly, calcineurin plays a role in skeletal muscle metabolism, fiber transformation, and hypertrophic remodeling, and modulates adaptive response to stimuli.

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