Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 339-342.doi: 10.3969/j.issn.1673-8225.2011.02.037

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Application of osteoprotegerin and basic fibroblast growth factor in periodontal regeneration

He Shi-hai1, Chen Qiao-er1, 2   

  1. 1Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei  230032, Anhui Province, China
    2Anhui Provincial Laboratory of Oral Disease Research, Hefei  230032, Anhui Province, China
  • Received:2010-09-02 Revised:2010-10-09 Online:2011-01-08 Published:2011-01-08
  • Contact: Chen Qiao-er, Professor, Chief physician, Master’s supervisor, Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei 230032, Anhui Province, China; Anhui Provincial Laboratory of Oral Disease Research, Hefei 230032, Anhui Province, China chqe0111@163.com
  • About author:He Shi-hai★, Studying for mater’s degree, Attending physician, Stomatology Hospital, College of Stomatology, Anhui Medical University, Hefei 230032, Anhui Province, China heshihai1970@sina. com
  • Supported by:

    the Science and Technology Plan for Society Development of Changzhou City, No. CS20092023

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Abstract:

BACKGROUND: Combination of osteoprotegerin and basic fibroblast growth factor can improve periodontal regeneration applying tissue engineering and gene therapy.
OBJECTIVE: To summarize theoretical basis for applying osteoprotegerin and basic fibroblast growth factor to improve periodontal regeneration.
METHODS: Relevant articles in PubMed (1996-2009) and CNKI (1999-2009) were searched by computer with the key words of “osteoprotegerin, basic fibroblast growth factor, tissue engineering, gene therapy, periodontal regeneration”. Articles addressing originality identification, reliability, general analysis, and high correlation were included. Exclusive criteria: repetitive and obsolescent articles. A total of 29 articles were reserved for review.
RESULTS AND CONCLUSION: How to obtain periodontal regeneration and to form new attachment is constantly hot spot in oral medicine research. Osteoprotegerin is a key factor in preventing osteoclasts differentiation and promoting bone formation. Basic fibroblast growth factor has extensive effects on embryo development, vascularization, bone restoration, cellular proliferation, and so on. Tissue engineering and gene therapy motivated the studies of periodontal regeneration progress. The selection of osteoprotegerin and basic fibroblast growth factor might be a method of treating periodontal diseases.

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