Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (2): 213-218.doi: 10.3969/j.issn.1673-8225.2011.02.006

Previous Articles     Next Articles

Construction of radius defect models: To standardize critical size defects

Zhao Ming-dong1, Pan Zhi-hong1, Zhu Liang-yu1, Yin Wang-ping1, Dong Jian2   

  1. 1Department of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai  200540, China
    2Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai  200032, China
  • Received:2010-09-02 Revised:2010-12-07 Online:2011-01-08 Published:2011-01-08
  • Contact: Dong Jian, Professor, Doctoral supervisor, Chief physician, Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China doctor_dong@126. com
  • About author:Zhao Ming-dong★, Master, Department of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai 200540, China zhaomingdong@ medmail.com.cn
  • Supported by:

    the Foundation of Science Commission of Jinshan District of Shanghai, No. 2009-3-01

PDF

1027

Abstract:

BACKGROUND: The length of radial bone defects are variant in different studies, which lack of reliable critical size defects (CSD).
OBJECTIVE: To investigate the standardization of the model of radial bone defect in rabbits, so as to obtain relatively reliable CSD.
METHODS: A total of 40 6-month New Zealand white rabbits including 80 radial bones were prepared for bone defect modelsAccording to the principle of randomization, the eighty radii which were operated for different length in bone defects were divided into 1.0-, 1.2-, 1.4-, 1.7- and 2.0-cm groups. X-ray film, gross anatomy, CT three-dimensional reconstruction, as well as tissue slices of the radius bone defect were carried out at 12 weeks after operation to evaluate the bone defect healing.
RESULTS AND CONCLUSION: At 12 weeks after operation, the healing rate was decreased from the 1.0- to 2.0-cm group, and the 1.4-cm group was lower than that of the 1.0- and 1.2-cm groups (P < 0.05). X-ray and CT grade of healing up of the 1.4-, 1.7-, 2.0-cm groups were smaller than those of the 1.0- and 1.2-cm groups (P < 0.05), which demonstrated that the bone healed well within 1.2-cm defects. The rabbit radial bone defect models were constructed successfully, which can be obtained by greater than or equal to 1.4-cm middle segmental defects (involving periosteum).

CLC Number: