Abstract:

BACKGROUND: The use of tissue engineered scaffold material is mature and diversifying for repairing cartilage damage, constructing tissue-engineered cartilage with similar biological properties to normal articular cartilage has become a research hotspot.
OBJECTIVE: To investigate the physiological characteristics and damage factor of the cartilage, to classify and summarize the current scaffold biomaterials in articular cartilage repair.
METHODS: A computer-based online search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) was performed, with the key words of “Cartilage, Damage, Biological Materials, Scaffold” in English and in Chinese to search the title and summary. Articles on treatment approach, materials science characteristics, biocompatibility and its application effect of cartilage scaffolds were selected, those recently published or published in the authority journals were preferred. A total of 28 articles were included.
RESULTS AND CONCLUSION: Human cartilage tissue is difficult to self-rehabilitate after injury, the implanted tissue engineered scaffold material serves as an important means of cartilage tissue repair. Choice for cartilage tissue engineering scaffolds has developed through natural materials, synthetic materials, and other single materials to composite material, the injectable materials, genetic technology and nano-materials, as well as modified materials technology are becoming currently a hot research and development trend.