Abstract:

OBJECTIVE: To investigate the feasibility, effectiveness and clinical value of alternative materials patch in pelvic floor reconstruction.
METHODS: An online search of VIP database and PubMed database was performed to retrieve relevant articles of pelvic floor dysfunction, pelvic floor reconstruction and the application of patch implants, with key words of “patch, pelvic floor reconstruction” in Chinese and “biological patch, reconstructive pelvic surgery” in English. Articles related to patch type, materials characteristics and application were included, those recently published or published in the authority journals were preferred in the same field. Duplicated research, reviews or Meta analysis were excluded, 16 articles were selected into the evaluation.
RESULTS: The biomaterial patch is divided into autologous, allogeneic and xenogeneic types. The autologous and xenogeneic grafts are mostly acellular tissue matrix at present, and its advantage is that there is no specific cognition site of cell surface receptors, it is difficult to trigger receptor immune rejection, thus increasing histocompatibility and reducing the probability of infection, some compound growth factors may exist and can regulate cell growth and induced differentiation. Synthetic patch materials have also been widely used in clinical practice, but may induce infection, rejection, invasion and other complications.
CONCLUSION: The emergence of biomaterial patch greatly avoids erosion, but the life, safety, and objective effect remain controversial.