Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (50): 9391-.doi: 10.3969/j.issn.1673-8225.2010.50.020

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Effect of Chinese medicine replenishing kidney and invigorating Qi on expression of interleukin-1 and interleukin-6 in synovial fluid of knee osteoarthritis 
 

Yuan Pu-wei, Liu De-yu, Yang Zhen-yuan, Chu Xiang-dong, Hao Yang-quan, Zhu Chao, Qu Qiang   

  1. Research&nbsp;Institute&nbsp;of&nbsp;Orthopedics&nbsp;and&nbsp;Traumatology,&nbsp;Shaanxi&nbsp;University&nbsp;of&nbsp;Chinese&nbsp;Medicine,&nbsp;Xianyang&nbsp;&nbsp;712000,&nbsp;Shaanxi&nbsp;Province,&nbsp;China</div>
  • Online:2010-12-10 Published:2010-12-10
  • About author:Yuan Pu-wei☆, Doctor, Associate professor, Associate chief physician, Research Institute of Orthopedics and Traumatology, Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China spine_surgeon@163.com
  • Supported by:

    the Scientific Research Plan Projects of Shaanxi Education Department, No. 09JK411*

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Abstract:

BACKGROUND: Osteoarthritis can be released or delayed rather than cured at present.
OBJECTIVE: To explore the mechanism of Chinese medicine with replenishing kidney and invigorating Qi on prevention of osteoarthritis.
METHODS: Long-eared white rabbits, aged 4 months, were randomly divided into six groups, control, model, traditional Chinese medicine high-, middle-, and low-dose and glucose-amino acid hydrochloride capsules groups. All animals were established osteoarthritis model and treated by traditional Chinese medicine with different doses or glucose-amino acid hydrochloride capsules for 4 weeks. The variations of interleukin-1 and interleukin-6 in joint fluid extraction were determined by ELISA. Gross and light microscope observations were performed on articular cartilages.
RESULTS AND CONCLUSION: The articular cartilage had varying degree degeneration, osteophyte and bone cysts formed and defects deep into middle zone of parts of cartilages after treatment. Compared with the control group, the synovial fluid interleukin-1 and interleukin-6 levels were obviously decreased in the traditional Chinese medicine high-, middle-, and low-dose and glucose-amino acid hydrochloride capsules groups (P < 0.05), and the decreased degree became greater with dose increasing. Chinese medicine with replenishing kidney and invigorating Qi can prevent osteoarthritis via reducing synovial fluid interleukin-1 and interleukin-6 levels.

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