Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (46): 8635-.doi: 10.3969/j.issn.1673-8225.2010.46.020

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Electro-acupuncture at Housanli (ST36) promotes the absorption of tanshinoneⅡA

Li Zhong-han1, Huang Lun2, Liu Li-wei1, Lu Jia1, Yu Bin2, Zhu Yi1, Xu Bin1, Fang Tai-hui2   

  1. 1Key Provincial-level Laboratory of Integrative Acupuncture and Drugs, Ministry of Education, Nanjing University of Traditional Chinese Medicine, Nanjing  210029, Jiangsu Province, China; 2Jiangsu Provincial Key Laboratory of the Evaluation of Efficacy and Safety, Nanjing University of Traditional Chinese Medicine, Nanjing  210029, Jiangsu Province, China
  • Online:2010-11-12 Published:2010-11-12
  • Contact: u Bin, Researcher, Professor, Master’s supervisor, Key Provincial-level Laboratory of Integrative Acupuncture and Drugs, Ministry of Education, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China xuuuux@sina.com Fang Tai-hui, Professor, Doctoral supervisor, Jiangsu Provincial Key Laboratory of the Evaluation of Efficacy and Safety, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China fangtaihui@sina.com
  • About author:Li Zhong-han, Key Provincial-level Laboratory of Integrative Acupuncture and Drugs, Ministry of Education, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China anyedejingling@gmail.com
  • Supported by:

    Students Practice Innovative Projects for Colleges and Universities in Jiangsu Province, No. 00396*

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Abstract:

BACKGROUND: In recent years, a large number of studies have shown that acupuncture combined with medication can synergy to improve myocardial ischemia, but the mechanism of this treatment has not been clarified.
OBJECTIVE: To observe the effects of electro-acupuncture of Housanli (ST36) in combination with oral doses of Salvia (varying concentrations) in the prevention of myocardial ischemia, and to observe the levels of tanshinone ⅡA in the blood and in myocardial muscle tissues after treatment.
METHODS: SD rats were randomly divided into the sham-surgery, model, low- and high- dose drug, and low- and high- dose drug + acupuncture groups. Electro-acupuncture was given on Housanli (ST36) in the adult SD rats following intragastric administration of 0.1 or 0.2 mg/L Danshen decoction. The changes of electrocardiogram T wave, heart and serum lactate dehydrogenase (LDH), and creatine kinase (CK) were observed after intragastric administration. HPLC was used for observation of tanshinone ⅡA concentrations in serum and cardiac tissues.
RESULTS AND CONCLUSION: Electro-acupuncture combined with different concentrations of Dansen decoction could protect the damage caused by myocardial ischemia by reducing the level of T wave and related enzymes. The content of Tanshinone ⅡA in the blood in the low dose and acupuncture group was higher than that in the low dose group in the same period (P < 0.05), but the content of Tanshinone ⅡA in the heart tissue in the low-dose + acupuncture group was not higher than that in the low-dose group (P > 0.05). Electro-acupuncture can promote the drug absorption in the low drug concentration, this role is mainly to promote the improvement of blood concentration, but does not increase the drug concentration on the target organ. Electro-acupuncture can promote drug absorption, thus, increasing the efficacy of the drug.

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