Abstract:

BACKGROUND: A large number of studies have demonstrated that orthopedic implant infection is related to bacteria biomembrane on the surface of materials. As the effect of general antibiotic is not favorable and the adverse effect is great, anti-infection method with opposing mechanism of bacteria biomembrane attachment release should be used.
OBJECTIVE: To explore predisposing factor and drug resistance factor following implanting and investigate effect of various antibiosis coating.
METHODS: A computer-based online search of Scopus database and Vip Chinese Periodical Database was performed for articled published between January 1990 and January 2010 related to infection following implant implantation, bacteria biomembrane and surface modification of implants.
RESUTLS AND CONCLUSION: The studies on the biocompatibility, wear-resisting and anti-corrosivity on the surface modification of implants are conducted, as well as the antibiosis. The idea of anti-bacterial surface modification of implants is widely accepted. It can be said that the "zero adhesion" of the bacteria is the ultimate goal of antibacterial modification. Although there are numerous studies of various anti-bacterial coating, the majority of them have focused on the pilot phase in vitro, related in vivo animal experiments are few. The immune defense mechanism of the body around the implant has been considered to play a major role in the implant infections. Therefore, the imminent problem requires further investigation to enhance the study on antibiotic modification with little effect on the bone fusion and the surrounding structures.