Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7907-7910.doi: 10.3969/j.issn.1673-8225.2010.42.028

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Tissue engineered nerve constructed with different materials and its application

Zheng Sheng-zhe1, Lu Lei2, Song Lei2   

  1. 1 Department of Neurology, Affiliated Hospital of Yanbian University, Yanji   133000, Jilin Province, China; 2 Department of Neurology, First Hospital of Jilin University, Changchun  130021, Jilin Province, China
  • Online:2010-10-15 Published:2010-10-15
  • About author:Zheng Sheng-zhe☆, Studying for doctorate, Attending physician, Department of Neurology, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China neurology@139.com

Abstract:

OBJECTIVE: To evaluate the performance of tissue engineered neural scaffolds and their use in repair of neural injury.
METHODS: Using “tissue engineering, tissue engineering nerve, artificial nerve, materials, repairing of neural injury” in Chinese and in English as the key words, a computer research was performed for articles between January 2000 and March 2010 about tissue engineering nerve scaffold material properties and its application in neural injury repair, duplicated study or Meta analysis were excluded.
RESULTS: A total of 20 articles mainly discussed the types and properties of tissue engineering nerve scaffold materials. Autologous nerve graft can be used as an ideal method applied to nerve tissue engineering, it not only has good biocompatibility, biodegradability and high affinity, also promote nerve growth factor growth and tissue repair, but the source is limited. Gelatin has no antigenicity, good biocompatibility, and can be completely biodegradable, achieve self-repair of nerve itself. Chitosan is a basic amino polysaccharide only greatly present in natural polysaccharide, has good biocompatibility, biodegradability and no toxicity, but still fails to meet the needs of being fully compatible. Nano-modification technology is expected to be used in following generation of tissue engineering nerve graft.
CONCLUSION: With the development of polymer materials science, more and more biodegradable synthetic materials have been shown to support neural regeneration, but an ideal nerve repair material is absent. It is a key to find a good neural scaffold that has a degradation rate to match neural regeneration speed, the best porosity, tube thickness, shape and so on, while nerve scaffolds achieve the greatest extent on the promotion of neural regeneration through the optimal choice with seed cells and neurotrophic factors.

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