Abstract:

OBJECTIVE: To describe the materials science of drug eluting stents, and to analyzes its biocompatibility.
METHODS: A computer research of PubMed database and China Academic Journal Full-text database was performed for articles about materials science and biocompatibility of drug eluting stents, using “cardiovascular, drug delivery, rapamycin, paclitaxel, coronary artery, biocompatibility, stents” as the Chinese key words. The literatures were primarily checked, and the citations of each literature were looked over. Duplicated study or Meta analysis was excluded.
RESULTS:  ① The drug-eluting cardiovascular stents are updated with aim to improve the biocompatibility and biomechanical properties. ② Cardiovascular stents biocompatibility is a complex chain process, blood compatibility and tissue compatibility are two basic elements for the assessment of the biocompatibility. ③ Analysis of mechanical properties of cardiovascular stents using finite element analysis provides helpful reference for the optimal design of future stent.
CONCLUSION: The study involved drug-eluting stents is an interdisciplinary crossing of pharmacology, biology and materials science, it is the key problems urgent to be solved in study of controlled release drug delivery system that to investigate the mechanism underlying drug controlled-release carrier, to find drug controlled-release carriers with better blood compatibility, and to enhance bonding strength between controlled-release carriers and the body.