Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (42): 7891-7894.doi: 10.3969/j.issn.1673-8225.2010.42.024

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Modification and application of medical poly(lactic acid) materials

Fan Guo-dong, Zhang Chun-mei   

  1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an   710021, Shaanxi Province, China　
  • Online:2010-10-15 Published:2010-10-15
  • About author:Fan Guo-dong☆, Doctor, Professor, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, Shaanxi Province, China fangd@sust.edu.cn
  • Supported by:

    Key Research Projects of Key Laboratory of Education Ministry of Shaanxi Province, No. 09JS061*; Graduate Innovation Fund of Shaanxi University of Science and Technology*

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Abstract:

BACKGROUND: Poly(lactic acid) is an aliphatic polyester with good biocompatibility and biodegradability. The main modified methods of poly(lactic acid) are chemical modification, physical modification and composite materials.
OBJECTIVE: To review the various modified methods and application research of poly(lactic acid), to put forward research direction of poly(lactic acid) materials.
METHODS: The Science Direct database, NSTL series database and full text database of Chinese Academic Journal from January 1999 to March 2010 were searched by computer for the articles of poly(lactic acid) modification, using “PLA, modification, medicine” in English and Chinese in title and summary as key words. Articles related to poly(lactic acid) modification were selected, those published recently or in the authoritative magazine were preferred in the same field. Totally 246 articles were searched after primary screen, according to the inclusive criteria, 46 articles were involved in review.
RESULTS AND CONCLUSION: Understanding of poly(lactic acid) modification is conducive to elect a more reasonable modifier and modified method, so that the mechanical and thermal properties of poly(lactic acid) are improved, and degradable cycle is controlled according to needs. Through the review of poly(lactic acid) modification, new product development and expanded application of poly(lactic acid) materials in medical field can be guided.

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