Abstract:

BACKGROUND: Guided tissue regeneration membrane is the key material in periodontal regeneration techniques, it guides gingival tissue growth clinically, excludes the epithelium from the periodontal defect, and provides an isolated space for the selective re-population of periodontal ligament, bone and cementum from the surface of dental root.
OBJECTIVE: To summarize the progress of guided tissue regeneration membrane and to provide reference evidence for carrying out guided tissue regeneration membrane clinically.
METHODS: Using “periodontal barrier membrane, guided tissue regeneration” in English and “guided tissue regeneration, periodontal” in Chinese as the key words, Pubmed database and CNKI database form January 2005 to May 2010 were searched for article related to clinical studies and animal experiments of guided tissue regeneration membranes. Totally 190 literatures were screened out by computer, according to inclusive and exclusive criteria, 25 documents were involved for analysis.
RESULT AND CONCLUSION: Because of the non-degradable materials, the first generation of guided tissue regeneration membranes need a second surgery to take out, thus aggravating the pains and impacting the healing. The present guided tissue regeneration membranes tend to the biodegradable materials, the pure natural bioplymers can not meet all needs of guided tissue regeneration membranes due to the property defects, while medical polymer materials, a combination with synthetic polymers, may exhibit excellent properties of the two and satisfy the clinical application. Although biological functional membranes are now under experimental study, the addition of specific agents as antibiotics, growth factors, adhesion factors, etc, conduces the periodontal tissue regeneration to promote the cell growth and induce the cell differentiation initiatively.