Abstract:

BACKGROUND: Basic fibroblast growth factor (bFGF) plays a promotive effect on cell proliferation and graft vascularization, which can facilitate human preadipocytes differentiate into adipocytes.
OBJECTIVE: To evaluate the effect of basic fibroblast growth factor on repairing facial depression deformity with autologous fat particle transplantation.
METHODS: A total of 54 patients with facial depression treated with autologous fat particle transplantation at the Affiliated Hospital of Medical College of Chinese People's Armed Police Force were selected. The patients were divided into control and bFGF groups according to chronological order. Patients in the control group were treated with pure fat particle transplantation, and patients in the bFGF group were treated by fat particle transplantation combined with bFGF. The therapeutic effects were observed through the comparison of the pre-post facial photos.
RESULTS AND CONCLUSION: The depression deformity of all the 54 patients was improved. There were 4 excellent and 6 good in the control group, with excellent and good rate of 63%. There were 12 patients received a second fat injection, and the ratio was 63.2%. In bFGF group, 14 excellent and 12 good, the excellent and good rate was 79%. Only 11 patients received a second fat injection, with the ratio of 33.3%. There was a significant statistical difference between the two groups (P < 0.05). Accordingly, local application of bFGF can enhance filling efficiency of facial depression.