Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (41): 7739-7742.doi: 10.3969/j.issn.1673-8225.2010.41.034

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Expression and regulatory mechanism of hepcidin

Liu Shu-xin1, Lu Hong-mei2, Liu Yu-qian1, Wang Hai-tao1, Kang Hong-zhe1, Li Wen-hui1, Chen Jun1   

  1. 1 College of Physical Education, Hebei Normal University, Shijiazhuang  050016, Hebei Province, China; 2 College of Physical Education, Anyang Normal University, Anyang  055000, Henan Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Liu Yu-qian, Doctor, Associate professor, Master’s supervisor, College of Physical Education, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China yuqianht@126.com
  • About author:Liu Shu-xin★, Studying for master’s degree, College of Physical Education, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China liushuxin19850725@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30700390*; the Natural Science Foundation of Hebei Province, No. C2009000291*

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Abstract:

BACKGROUND: The cellular iron efflux is modulated by hepcidin derived by liver and this peptide is now regarded as the central regulator of body iron homeostasis. Hepcidin expression is influenced by regulators such as iron store, the rate of erythropoiesis, inflammation, hypoxia and oxidative stress. These regulators control the content of hepcidin by proteins on hepatocyte, such as HFE, transferrin receptor 2, hemojuvelin and the IL-6R and so on. These proteins activate various cell signal transduction pathways, including the BMP-SMAD, JAK-STAT and HIF1 pathways. As a result, the expression of hepcidin is altered. However, the detail molecular mechanism of hepcidin expression remains unclear.
OBJECTIVE: To summarize the regulatory mechanism of hepcidin from the aspects of signal factor and signal pathway.
METHODS: Literatures in NCBI and SpringerLink databases from 2000 to 2010 were searched by the first author using key words of “hepcidin, hemochromatosis, hemojuvelin, BMP signaling pathway, HFE, transferrin receptor 1, transferrin receptor 2”. The latest research regarding regulatory mechanism of hepcidin was analyzed from the aspects of signal factor and signal pathway.
RESULTS AND CONCLUSION: Totally 210 papers were searched by computer, and 37 documents were included according to inclusive and exclusive criteria. The results showed that hepcidin expression was influenced by signal factors such as hereditary hemochromatosis, transferrin receptor 1, and transferrin receptor 2. These proteins activate various cell signal transduction pathways, including the BMP-SMAD, JAK-STAT and HIF1 pathways. As a result, the expression of hepcidin was altered.

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