Abstract:

BACKGROUND: Neural regulation of fracture healing is a complex process. The denervation of fracture healing is a hot issue.
OBJECTIVE: Through comprehensive research progress in recent years, this paper retrospective analyze the effect of various components and levels of nerve injury on fracture healing, and to explore the factors of fracture healing after nerve injury and its mechanism.
METHODS: A computer-based research was conducted in VIP, CNKI, PubMed and Highwire database from 1993 to 2009 using key words of “fracture healing; nerve injuries; neuropeptides; growth factors” both in English and Chinese, and literature references were manual retrieved. Documents related to bone healing, denervation, and relationship between nerve injury and fracture healing were included. The irrelative, repetitive research or old data were excluded.
RESULTS AND CONCLUSIONS: A total of 1 638 literatures were collected, including 686 Chinese literatures and 952 English literatures. Through reading titles and abstracts, 28 standard literatures were included. Fracture healing is a complex process, subject to multi-level and multi-route regulations of the general and local environments in the body, and in this process many growth factors involved. Different components and levels of nerve injury have significant influence to fracture healing. The patients who have sustained a traumatic brain injury and limb fracture patients, a lot of callus around the fracture site is increased significantly, the heterotopic ossification in the muscle even appeared, and the rate of fracture healing was faster than the patients with simple fracture.