Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (41): 7731-7734.doi: 10.3969/j.issn.1673-8225.2010.41.032

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Role of osteogenic protein-1 in disc degeneration and repair

Liu Hang-tao1, Wang Wan-ming2, Lin Zhi-jun1   

  1. 1 Department of Orthopaedics, First Hospital of Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Putian  351100, Fujian Province, China; 2 Department of Orthopaedics , Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou  350025, Fujian Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Wang Wan-ming, Doctor, Chief physician, Master’s supervisor, Department of Orthopaedics , Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou 350025, Fujian Province, China wangwm93@126.com
  • About author:Liu Hang-tao★, Master, Physician, Department of Orthopaedics, First Hospital of Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Putian 351100, Fujian Province, China liuhangtao_2000@163.com

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Abstract:

BACKGROUND: How to regeneration and repair intervertebral discs puzzles doctors in orthopedics. With a strong osteoinductive activity, osteogenic protein-1 can induce bone and cartilage formation in vivo.
OBJECTIVE: To summarize and discuss the effects of osteogenic protein-1 on disc degeneration and repair.
METHODS: Databases of China Journal of Full-text Database (CNKI) and PubMed were searched by the first author using key words of “intervertebral disc; degeneration; osteogenic protein-1/bone morphogenic protein-7” to find papers published between 1990 and 2010 both in Chinese or English. The effects of osteogenic protein-1 on intervertebral disc cells and its degeneration both in vitro and in vitro were introduced.
RESULTS AND CONCLUSION: Totally 56 papers were retrieved by computer, and 27 documents were selected according to the inclusive and exclusive criteria. As a result, osteogenic protein-1 has an effect on promoting disc cells synthesizing collagen and proteoglycan, can adjust and restorate the metabolism of extracellular matrix in disc degeneration, and shows a bright future to retard disc degeneration.

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