Abstract:

BACKGROUND: With the research developments of adipose tissue, the effect of adipose tissue on wound healing has aroused increasing attention. The mechanisms of wound healing accelerated by adipose tissue and its application have been widely carried out. 
OBJECTIVE: To provide the theoretical basis for clinical wound treatment via investigating the mechanisms of adipose tissue on accelerate wound healing from aspects of adipokines/adipocytokines and adipose-derived stem cells and reviewing their applications.
METHODS: CNKI and PubMed databases were searched by the first author using key words of “adipose tissue, leptin, resistin, adipose-derived stem cells, wound healing” from 2009 to 2010. The language was limited for Chinese and English. The mechanisms of adipose tissue on accelerate wound healing and their applications were introduced from adipokines/adipocytokines and adipose-derived stem cells.
RESULTS AND CONCLUSION: A total of 329 papers were searched, and 31 documents were included according to inclusive criteria. The results showed that, the proliferation of vascular regeneration, fibroblast and keratinocytes play a key role in wound healing, adipose tissue can promote and improve the quality of wound healing through the proliferation of vascular endothelial, fibroblasts, keratinocytes and other cells. However, the regulation of adipokines/adipocytokines during wound healing, the mechanism of adipose-derived stem cells proliferation and differentiation, as well as how to improve the healing rate, remain poorly understood.