Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (41): 7704-7708.doi: 10.3969/j.issn.1673-8225.2010.41.025

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Biomechanical and pathological changes of rat tendon following short-term local glucocorticosteroid injection

Ji Shu-qing 1,2 , Ma Xin-long 1,3, Ma Jian-xiong1, Zhu Shao-wen3, Yang Yang1   

  1. 1 Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin  300052, China; 2 Department of Orthopedics, the People’s Hospital of Jixian County, Tianjin  301900, China; 3Tianjin Hospital, Tianjin  300211, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Ma Xin-long, Master, Professor, Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin 300052, China; Tianjin Hospital, Tianjin 300211, China
  • About author:Ji Shu-qing★, Studying for master’s degree, Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin 300052, China; Department of Orthopedics, the People’s Hospital of Jixian County, Tianjin 301900, China jshq0_wmh6818@sina.com.cn
  • Supported by:

     the Natural Science Foundation of Tianjin, No. 043111411*; 993607711*

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Abstract:

BACKGROUND: The long-term local injection of glucocortico steroid have a negative impact on the tendon, but the short-term application is still in dispute. 
OBJECTIVE: To observe the biomechanical and pathological changes of rat tendon following short-term glucocorticosteroid local injection.     
METHODS: Rats in the hormone blockade control and hormone blockade training groups were injected dexamethasone with human body suitable dose once weekly and three times totally. Treadmill exercise was supplemented to rats in the hormone blockade training group, with intensity of 25 m per minutes, 30 minutes per time, and three times weekly. There was no treatment on rats in the normal control group. Hematoxylin-eosin staining and MASSON staining were used to observe tendon histological alterations. Tension test was performed to observe the biomechanical changes.
RESULTS AND CONCLUSION: Biomechanical features of the hormone blockade control group appeared earlier reinforced and lately degraded, and a case of tendon rupture was found. The mechanics efficiency of tendon in the hormone blockade training group showed earlier degraded and lately recovered. Tendon cataplasia could be found in these two groups. Short-term local glucocorticosteroid injection can stimulate and decline the flexibility of the tendon. Strong physical strength work should be avoided and moderate functional exercise should be done when use it.

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