Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (41): 7661-7664.doi: 10.3969/j.issn.1673-8225.2010.41.015

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Expression of tissue inhibitor of matrix metalloproteinases and type Ⅳ collagen in growing rat masticatory muscle after functional mandibular protrusion

Sun Hui-ling1, Zhou Hong2, Zou Min2   

  1. 1 Research Center for Stomatology, 2 Department of Orthodontics, Stomatology Hospital of Xi’an Jiaotong University, Xi’an  710004, Shaanxi Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Zhou Hong, Professor, Department of Orthodontics, Stomatology Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • About author:Sun Hui-ling☆, Studying for doctorate, Attending physician, Research Center for Stomatology, Stomatology Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China sunhuil@mail.xjtu.edu.cn
  • Supported by:

    the Tackle Key Program in Science and Technology of Shaanxi Province, No. 2006k11-G6(2)*

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Abstract:

BACKGROUND: Rat masticatory muscle presented with adaptability and remodeling during functional mandibular protrusion, and matrix metalloproteinases was involved in this process.
OBJECTIVE: To investigate tissue inhibitor of matrix metalloproteinases (TIMPs) and collagen type Ⅳ changes in growing rat masticatory muscle after functional mandibular protrusion.
METHODS: Healthy male Sprague Dawley rats, aged 4 weeks, were randomly divided into the experimental and control groups. Rats in the experimental group wear appliance 10-12 hours per day. The expressions of TIMP-1, TIMP-2 and type Ⅳ collagen in growing rat masticatory muscle were measured at 3, 7, 14 and 21 days by immunohistochemistry.
RESULTS AND CONCLUSION: TIMP-1, TIMP-2 and type Ⅳ collagen were expressed in digastric muscle in all groups. However, compared with the control group, the expression of TIMP-1, TIMP-2 and type Ⅳ collagen was enhanced in the experimental group, which suggested that, TIMP-1, TIMP-2 and collagen type Ⅳ involve changes in growing rat masticatory muscle after functional mandibular protrusion.

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