Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (41): 7639-7642.doi: 10.3969/j.issn.1673-8225.2010.41.010

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Design of an embedded real-time detecting and controlling system for tissue engineered bioreactor

Liu Kuang-bin1, Huang Hua1, Zeng Jun2, Liu Yi3   

  1. 1 Department of Medical Information Engineering, 2 Department of Signal and Information Processing, School of Electrical Engineering and Information, Sichuan University, Chengdu  610065, Sichuan Province, China; 3 Southwest Institute of Technical Physics, Chengdu  610041, Sichuan Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Huang Hua, Doctor, Professor, Doctoral supervisor, Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu 610065, Sichuan Province, China hhua@scu.edu.cn
  • About author:Liu Kuang-bin★, Studying for master’s degree, Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu 610065, Sichuan Province, China cairmy@163.com
  • Supported by:

     the Applied Basic Research of Sichuan Province, No. 07JY029*; the Innovation Foundation of Sichuan University, No. 2005CF14*

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Abstract:

BACKGROUND: Tissue engineering bioreactor is used to simulate the cell’s metabolism in vivo and provide a condition to culture the three dimensional cells and tissue in vitro.
OBJECTIVE: To analyze the bioreactor’s needs for culturing and design a detecting and controlling system based on Linux and ARM9 embedded processor for the bioreactor.
METHODS: The system was used to control and detect the bioreactor made by our laboratory. The experiment contained preparing the scaffold and devices (Auto desktop sterilizer, gas-liquid membrane, gas-gas membrane and so on), bone marrow mesenchymal stem cells cultivation, the controlling of bioreactor, as well as detections of temperature, oxygen partial pressure, and pH value.
RESULTS AND CONCLUSION: Compared with the system based on MCU, the new design improved the driving and parameter detecting and added the oxygen partial pressure and pH monitoring modules. The function of the bioreactor was perfect. 

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