Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (40): 7564-7567.doi: 10.3969/j.issn.1673-8225.2010.40.035

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Application of induction and differentiation of neural stem cells in the field of sports medicine

Zhang Ke-bin1, Liu Rui-lian2　   

  1. 1 Department of Physical Education, Qinzhou University, Qinzhou  535000, Guangxi Zhuang Autonomous Region, China; 2 Physical Education Institute, Yichun University, Yichun  336000, Jiangxi Province, China 　
  • Online:2010-10-01 Published:2010-10-01
  • Contact: Liu Rui-lian, Master, Lecturer, Physical Education Institute, Yichun University, Yichun 336000, Jiangxi Province, China
  • About author:Zhang Ke-bin, Lecturer, Department of Physical Education, Qinzhou University, Qinzhou 535000, Guangxi Zhuang Autonomous Region, China huayan331@163.com

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Abstract:

BACKGROUND: Neural stem cells (NSCs) with their self-renewal, multi-directional differentiation, proliferation, division, injury and disease on the characteristics of strong reaction with the nervous system for a variety of genetic diseases and acquired diseases have brought new hope.
OBJECTIVE: To summarize NSC differentiation and its mechanisms, and to explore its application to sports medicine research.
METHODS: A computer-based online search was performed in the PubMed database and Chinese journal full-text database for articles published from 1994 to 2010 concerning NSCs and exertional disease.
RESULTS AND CONCLUSION: At present, the role of the NSCs in myocardial ischemia, myocardial infarction, neuronal injury, spinal cord injuries and other related diseases research has achieved some achievements, and the application to sports medicine research has broad prospects. Although the NSCs with the diversity of its potential and have the advantage of self-renewal are extensively used in clinic, there are still many problems to be resolved, such as progenitor cells of NSCs and the NSCs to further differentiate into neurons or glial cells whether it has a specific function; in vitro induced NSCs to be transplanted into neural tissue and directional migration, whether they have compatibility of autologous nerve cells in the body and the host, whether they can survive and proliferate for a long term; in vitro-induced NSCs play a role in nerve repair in the integration of autologous neural cells in the host. The research of induced differentiation of NSCs in other sports injuries has not yet been solved.

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