Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (38): 7087-7090.doi: 10.3969/j.issn.1673-8225.2010.38.014

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Preparation of polylactic-co-glycolic acid morphine microspheres and their analgesia effect

Zhang Xu-hui1, Sun Yong-hai2, Zhang Hong2   

  1. 1 Department of Anesthesiology, the 305 Hospital of Chinese PLA, Beijing   100017, China; 2 Department of Anesthesiology, General Hospital of Chinese PLA, Beijing   100853, China
  • Online:2010-09-17 Published:2010-09-17
  • About author:Zhang Xu-hui★, Master, Associate chief physician, Department of Anesthesiology, the 305 Hospital of Chinese PLA, Beijing 100017, China dandelion595@yahoo.com.cn
  • Supported by:

    Special Project of the "Eleventh Five-year Plan" for Medical Science of Chinese PLA*

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Abstract:

BACKGROUND: Drug microspheres have become a new drug delivery system because of the targeting on specific organs and tissues, as well as slow-release of drugs in particles. Scholars have conducted a series of studies on local anesthetic drug slow-release delivery system, but preparation of narcotic analgesic microspheres is rarely reported.
OBJECTIVE: To prepare biodegradable slow-release microspheres based on polylactic-co-glycolic acid (PLGA) and morphine, to study the analgesia effect.
METHODS: Morphine-PLGA microspheres were prepared by using emulsify-solvent evaporation method, their entrapment efficiency and drug loading content were determined. Healthy male SD rats were divided into 3 groups randomly: blank control group (hypodermic injection of physiological saline), positive control group (hypodermic injection of morphine), microsphere group (hypodermic injection of morphine-PLGA microspheres). The pain threshold was detected using CO2 laser as thermal stimulus.
RESULTS AND CONCLUSION: The morphine-PLGA microspheres were white powders. The entrapment efficiency and drug loading were 33% and 11.86%, respectively. The morphine-PLGA microspheres could prolong the time of analgesia to above 6 hours. Results demonstrated that the morphine-PLGA microspheres play a remarked prolonging role in release time of morphine, and result in a good slow-release, but the time is not enough for the expected time, so the method to prepare microspheres should be further modified.

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