Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (38): 7045-7047.doi: 10.3969/j.issn.1673-8225.2010.38.004

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Preparation and properties of calcium polyphosphate fiber reinforced poly (D-lactide) as cartilage tissue engineered scaffold

Wang Yan-ping1, Zhang Fa-qi1 ,Wang Xiu-li2, Zhu Ling-yun1　   

  1. 1 School of Mechatronic Engineering, Lanzhou Jiaotong University, Lanzhou   730070, Gansu Province, China; 2 School of Information Engineering, Lanzhou City University, Lanzhou   730070, Gansu Province, China
  • Online:2010-09-17 Published:2010-09-17
  • About author:Wang Yan-ping★, Master, Associate professor, School of Mechatronic Engineering, Lanzhou Jiaotong University, Lanzhou 730070, Gansu Province, China wangyp@mail.lzjtu.cn
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 096RJZA085*; University Students Innovative Program in Science and Technology by Lanzhou Jiaotong University, No. DXS2010-012*

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Abstract:

BACKGROUND: Conventional scaffolds, such as polylactic acid, polyglycolic acid and copolymers of the two, have good biocompatibility, and have been widely used in manufacturing cell delivery and tissue engineered scaffolds. However, they are easily deformed, and degrade for a long time.
OBJECTIVE: To prepare a composite scaffold of calcium polyphosphate fiber reinforced poly (D-lactide) for cartilage tissue engineering, to perform experimental study and theoretical analysis of the physical, mechanical characteristics and degradation, and to verify the feasibility of optimizing compounding.
METHODS: Taking calcium polyphosphate fiber as reinforced materials and poly (D-Lactide) as matrix materials in a ratio of 67/33, the composite scaffolds for cartilage tissue engineering were fabricated by solvent-casting particulate-leaching and gas foam methods, and their properties of physical mechanics and degradation were tested.
RESULTS AND CONCLUSION: The prepared composite scaffolds exhibited high porosity, arranging 80%-93%. The scaffolds have higher compressive modulus than polylactic acid scaffolds, and showed controllable degradation characteristics, which can provide three-dimensional microenvironment for cell proliferation. The composites of calcium polyphosphate fiber reinforced poly (D-Lactide) can meet the mechanics and degradation demand of cartilage tissue engineering, so they can be used as scaffolds for cartilage tissue engineering.

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