Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (38): 7037-7040.doi: 10.3969/j.issn.1673-8225.2010.38.002

Previous Articles     Next Articles

In vitro study of bone adhesive mainly composed of sodium alginate

Zhang Jian-xin1, Gao Ya-hui2, Pan Zhuang-zhuang1, Cai Zhen-zhen1, Lin Yu-yang1   

  1. 1 Xiamen Traditional Chinese Medicine Hospital, Xiamen   361009, Fujian Province, China; 2 Xiamen University, Xiamen   361009, Fujian Province, China; 3 Department of Surgery, Huanghe Hospital, Jinan   250032, Shandong Province, China
  • Online:2010-09-17 Published:2010-09-17
  • About author:Bhang Jian-xin☆, Doctor, Chief physician, Xiamen Tradition Chinese Medicine Hospital, Xiamen 361009, Fujian Province, China fjzjx@126.com
  • Supported by:

    Science Research Foundation of Ministry of Health & United Fujian Provincial Health and Education Project for Tackling the Key Research, No. WKJ2005-2-018*

PDF

444

Abstract:

BACKGROUND: The ideal treatment for comminuted fracture is to directly bind bone fragments using adhesive, medical adhesive has been widely used in clinical practice. But little information is available regarding the biogel derived from the plants for the fixation of fracture block.
OBJECTIVE: To prepare a new biological adhesive mainly composed of alginate gels that can fix bone fracture block in vitro and observe the binding effect.
METHODS: The cortex bones of femur from commercially available fresh pigs were prepared into 2-cm2 bone blocks whose area of section was about 1 cm2. The alginate gels were mingled with sodium carboxymnthyl cellulose and guar gum separately in certain proportion. The bone specimens were fixed by the glue and then cured with calcium chloride solution. Shear stress force of the bone blocks was measured on the day of the experimentation, and 1, 2, 3 weeks after saline infiltrated.
RESULTS AND CONCLUSION: The adhesive bonding strength had a normal distribution curve over time, and reached the peak one week later (shear stress was 17 000 σ/Pa), then gradually reduced. The adhesives could firmly fix 1-cm2 bone blocks. Modified alginate gel with suitable tackifier could fix small bone block.

CLC Number: