Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (20): 3797-3800.doi: 10.3969/j.issn.1673-8225.2010.20.043

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Current research and development of tissue engineered venous valve

Yuan Jian-ming, Dang Rui-shan, Shen Man-ru, Zhang Chuan-sen   

  1. Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai   200043, China
  • Online:2010-05-14 Published:2010-05-14
  • Contact: Zhang Chuan-sen, Professor, Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai 200043, China chuansen@yahoo.com
  • About author:Yuan Jian-ming, Studying for doctoral degree, Laboratorian in charge, Institute of Biomedical Engineering, Second Military Medical University of Chinese PLA, Shanghai 200043, China yjmdragon@ yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30672045*;
    Natural Science Key Projects of Shanghai, No. 08441900600*

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Abstract:

OBJECTIVE: To review the current research of tissue engineered venous valve at home and abroad, to analyze the developing trend of tissue engineered venous valve in the clinical application.
METHODS: A computer retrieve was performed among PubMed, ProQuest Health & Medical Complete database, Springer English Academic Journal Full-text database, Elsevier Full-text database between January 2000 and August 2009, with the key words of “tissue engineering venous valve”, and the language was limited to English. At the same time, Chongqing VIP database, Qinghua Academic Journals Database, Chinese Biomedical Literature database were also screened on computer by using the key words “tissue engineered venous valve”, and the language was limited to Chinese. In addition, the relevant monographs were manually checked.
RESULTS: The comprehensive analysis shows that an ideal method to construct tissue engineered venous valve is to combine progenitor cells with multipotent adult progenitor cells for the batched incubation in allogenic acellular vein scaffolds, in vivo environment can be maximally simulated through constant pressure perfusions on the three-dimensional culture system, thus seed cells can well grow into functional tissue engineered venous valve on the scaffold materials. This study provides experimental basis for clinical application of venous valve tissue engineering.
CONCLUSION: At present, tissue engineered venous valve research has made considerable progress and encouraging results, brings first lights for deep venous insufficiency for patients, and exhibits wide application in the field of deep venous insufficiency treatment.

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