Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (20): 3762-3767.doi: 10.3969/j.issn.1673-8225.2010.20.036

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Association between primary hypertension accompanying carotid atherosclerosis and paraoxonase 2 polymorphisms in Uighur and Han populations: A 3-year report of 430 cases in the same institute

Zhao Fang1, Xu Xin-juan1, Ma Yan-ping2, Ren Rong3, Ma Jie1, Liang Xiao-hui1   

  1. 1Department of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uighur Autonomous Region, China;
    2Department of Hypertension, Urumqi Armed Police Hospital, Urumqi  830054, Xinjiang Uighur Autonomous Region, China;
    3Department of Nephropathy, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uighur Autonomous Region, China
  • Online:2010-05-14 Published:2010-05-14
  • Contact: Xu Xin-juan, Professor, Chief physician, Doctoral supervisor, Department of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China zcxu2002@medmail.com.cn
  • About author:Zhao Fang, Studying for master’s degree, Associate chief physician, Department of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China Zwj13999823220@163.com
  • Supported by:

    the Science and Technology Project of Urumqi, No. Y05331001*

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Abstract:

BACKGROUND: Recently studies demonstrated that paraoxonase-2 (PON2) can decrease low density lipoprotein overoxidation and protect tissues against oxidation damage.

OBJECTIVE: To investigate the relationship between PON2 polymorphisms (PON2 C311S) and primary hypertension accompanying carotid atherosclerosis.

METHODS: The study comprised 430 participants who admitted at the First Affiliated Hospital of Xinjiang Medical University were collected and divided into 2 groups: primary hypertension accompanying carotid atherosclerosis (n=294) and primary hypertension without carotid atherosclerosis (n=136). The case group was consisted of 214 Han people and 80 Uighur people. The control group consisted of 103 Han people and 33 Uighur people. Genotypes were detected by polymerase chain reactions followed by restriction analyses with specific endonucleases and their frequencies were determined. 

RESULTS AND CONCLUSION: The CC+CS genetype distribution and the C allele frequency of the PON2 C311S gene were obviously increased in the Han case group than that of the control group. Diastolic blood pressure of Han people with three genetypes (SS, CS, CC) exhibited a significant difference (P=0.003), especially greatest in the CC genetype. Logistic regression analysis demonstrated that allele of PON2 C311, age, diastolic blood pressure, lipoprotein (a) were the risk factors of hypertension accompanying carotid atherosclerosis (P < 0.05). The genetype and C allele frequency of PON2 C311S gene was greater in the Uighur case group than that of the control group, and the low density lipoprotein exhibited a significant differences in Uighur people with three genetypes (P=0.005), especially highest in the CC genotype. The single nucleotide polymorphism of PON2C311S is probably associated with carotid atherosclerosis in primary hypertension people of Chinese Han population in Xinjiang. The C allele might be a risk factor.

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