Abstract:

BACKGROUND: Spinal cord injury, especially obsolete spinal cord injury-induced paralysis, is a more serious disability. How to treat spinal cord injury with effective therapy then doing functional reconstruction are difficulties in the clinic.
OBJECTIVE: To explore effective methods for repair of obsolete spinal cord injury and reconstruction of nerve function, and to summarize the clinical experiences.
METHODS: Papers related to therapy for obsolete spinal cord injury and nerve functional reconstruction published between October 1996 and December 2009 in CNKI and between October 1999 and October 2009 in PUBMED database were searched with key words of “obsolete spinal cord injury; nerve functional reconstruction, cell transplantation, surgery, spasm pain” in Chinese and English. The articles regarding obsolete spinal cord injury, cell transplantation or nerve functional reconstruction were selected, and the duplicated study or Meta analysis was excluded.
RESULTS AND CONCLUSION: Totally 107 literatures were collected, and 61 of them were excluded, thus, 46 documents were included. Analysis results showed that for obsolete incomplete injury, cell transplantation and microsurgery can stimulate nerve cells regeneration, remove compressions on spinal cord and nerve root, and thus, promote the recovery or regeneration. For complete injury, the normal peripheral nerve bypass on the paraplegia plane can be connected to the nerve on the plane, which can reconstruct diaphragmatic respiratory function, partial upper limb and hand function, walking, defecation and plantar sensory, therefore, this method is a feasible treatment strategy.