Abstract:

BACKGROUND: Hyperplastic scar is the abnormal results of wound healing, which severely effects body appearance and leads to functional disturbance.

OBJECTIVE: To review the prevention and treatment of hypertrophic scar status in China and abroad.

METHODS: PubMed, Embase, Chinese Biomedical Literature Database, CNKI, CAJ were retrieved by computer with key words of “hypertrophic scars, prevention and treatment”. The language was limited for English and Chinese. Simultaneously, related monograph was manually searched. The studies regarding biological features of hypertrophic scar, reasons for hypertrophic scar formation, as well as prevention and treatment of hypertrophic scar were included in the analysis.

RESULTS AND CONCLUSION: The main causes of hypertrophic scar fibroblasts are biological characteristics of abnormal increase in the number of fibroblasts. A large number of collagen fibers synthesized and secreted is the key to the formation of scar tissue. The prevention and treatment of hypertrophic scar should be integrated early in wound healing to take preventive measures to curb scar. Treatment should be combined in several ways to take combination therapy, which received notable results compared with monotherapy. In addition, in recent years the role of Chinese medicine in the mechanism of scar formation, animal experiments and dose reconstruction studies are endless. Strengthening of Chinese medicine in prevention and treatment of hypertrophic scar research is very important. The occurrence and development of abnormal scars should be thoroughly avoided or reduced from the source, genetic level defects should be amended to prevent and treat hypertrophic scars. Traditional Chinese medicine can be a further breakthrough in the prevention and treatment of hypertrophic scars.