Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (20): 3748-3752.doi: 10.3969/j.issn.1673-8225.2010.20.033

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Effects of exercise on mitogen-activated protein kinases signaling pathway in skeletal muscle

Hong Xiong1, Zhang Wei2   

  1. 1Department of Physical Education, Jiangxi Normal University, Nanchang  330027, Jiangxi Province, China;
    2Department of Physical Education, Jiangxi University of Traditional Chinese Medicine, Nanchang  330004, Jiangxi Province, China
  • Online:2010-05-14 Published:2010-05-14
  • About author:Hong Xiong, Master, Lecturer, Department of Physical Education, Jiangxi Normal University, Nanchang 330027, Jiangxi Province, China hx6626@yahoo.com.cn

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Abstract:

BACKGROUND: Mitogen-activatedprotein kinases (MAPKs) are serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis.

OBJECTIVE: To summarize the important effects of MAPKs on postexercise skeletal muscle.

METHODS: The Chinese Full Text Databases (website: http://dlib.cnki.net/kns50/index.aspx) and PubMed (website: http://www. ncbi.nlm.nih.gov/pubmed/) were retrieved by computer from 1990-01 to 2009-06 with key words of “exercise, mitogen-activated protein kinases, skeletal muscle and adaption”. The papers concerning research status and development trend of exercise on MAPK were included, and the repeated research was excluded.

RESULTS AND CONCLUSION: Exercise can activate MAPK signal transduction system of skeletal muscle, and different types of exercises, skeletal and training times had varying effects on MAPKs. MAPKs are involved in skeletal muscle adaption and exhibited different time courses after exercise. The study of adaptability changes of MAPKs on postexercise skeletal muscle is conductive to prepare and develop motor function foods or antifatigue drugs.

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