Abstract:

BACKGROUND: The mechano growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), is involved in tissue repair and adaptation. Therefore, the application of exogenous MGF on interfering satellite cells and regulating molecular mechanism provides a new idea for treating muscle damage.
OBJECTIVE: To analyze the regulation of MGF on skeletal muscle satellite cells and its clinical effects.
METHODS: The relevant articles between 1995 and 2009 were retrieved from PubMed and CNKI database using key words of “mechano growth factor; skeletal muscle satellite cells”, and restricting the language as English and Chinese by computer. The original articles with representation in the objectives or methods were included, and the repetitiveness or unrelated papers were excluded.
RESULTS AND CONCLUSION: The MGF could activate skeletal muscle satellite cells, promote cells proliferation, inhibit myotube integration and facilitate the migration of satellite cells, which had positive clinical effect on skeletal muscle repair, nerve repair and the treatment of myocardial infarction. The effects of exogenous MGF on promoting regeneration and repairing muscle tissue injury may open up a new avenue for sports damage, as well as exhibit an important role in satellite cell transplantation.