Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (20): 3736-3739.doi: 10.3969/j.issn.1673-8225.2010.20.030

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Pathophysicological mechanism of discogenic low back pain and tissue engineering technique

Jiang Zheng, Yin Zong-sheng   

  1. Second Ward of Department of Orthopedics, First Hospital of Anhui Medical University, Hefei  230022, Anhui Province, China
  • Online:2010-05-14 Published:2010-05-14
  • Contact: Yin Zong-sheng, Chief physician, Professor, Doctoral supervisor, Second Ward of Department of Orthopedics, First Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • About author:Jiang Zheng, Studying for master’s degree, Second Ward of Department of Orthopedics, First Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China jiangzheng_jlx@126.com

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Abstract:

BACKGROUND: The pathogenesis of discogenic low back pain remains controversial. The understanding of pathophysicological mechanism provides important theoretical foundation for clinical diagnosis and treatment.

OBJECTIVE: To review the pathophysicological mechanism of discogenic low back pain and application of tissue engineering at home and abroad.

METHODS: A computer-based online search of Pubmed (1980-01/2009-08) and CNKI (2000-01/2009-08) was performed for articles in English and Chinese with the key words “discogenic low back pain, low back pain” in English and Chinese. In addition, manual search was performed. Studies regarding pathophysicological mechanism of intervertebral degeneration and pathophysicological mechanism of intervertebral disk hernia-induced pain were included.

RESULTS AND CONCLUSION: Chronic low back pain is partially caused by intervertebral disk lesion. Natural degeneration and mechanical pressure changes lead to the breakdown of nucleus pulposus and annulus fibrosus. Through the breakdown of nerve fibers, nerve fibers grow into the disc. The nucleus of disc can stimulate surrounding tissue to produce inflammatory cytokines, which stimulate pain from nerves. The change of the waist mechanical stress can increase pain. Traditional surgical treatment, such as discectomy, lumbar fusion, intradiscal radiofrequency ablation, will reduce the height of normal spine and spine segment activities. The promotion of the regeneration of intervertebral disc and the disc replacement surgery may solve this problem. Therefore, treatment of discogenic low back pain with tissue engineering has become a new interesting topic.

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