Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (20): 3625-3628.doi: 10.3969/j.issn.1673-8225.2010.20.004

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Autologous periosteum wrapping tendon combined with basic fibroblast growth factor as substitute for the lunate bone  

Meng Zhao1, Tian Li-jun2, Shao Xin-zhong3   

  1. 1Department of Orthopaedics, Hebei Children’s Hospital, Shijiazhuang  050031, Hebei Province, China;
    2Department of Hand Surgery, Third Hospital of Shijiazhuang, Shijiazhuang  050031, Hebei Province, China;
    3Department of Hand Surgery, Third Hospital of Hebei Medical University, Shijiazhuang  050051, Hebei Province, China
  • Online:2010-05-14 Published:2010-05-14
  • About author:Meng Zhao, Master, Master’s supervisor, Chief physician, Professor, Department of Orthopaedics, Hebei Children’s Hospital, Shijiazhuang 050031, Hebei Province, China mz285@163.com

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Abstract:

BACKGROUND: The silica gel prosthesis and os lenticulare were widely used as substitute for lunar bone, which can result in complications, such as periostitis, bone resorption as well as carpal bone collapse.

OBJECTIVE: To study the feasibility of autologous periosteum wrapping tendon combined with basic fibroblast growth factor (bFGF) as substitute for the lunate bone in treatment of aseptic necrosis.

METHODS: Totally 45 healthy New Zealand white rabbits were randomly divided into 3 groups: periostum wrapping tendon group, periostum wrapping tendon combined with bFGF group and tendon group, with 15 animals in each group. The implants were prepared by autologous periosteum of tibia wrapping partial patellar tendon combined with bFGF. The three sorts of implants were placed into articular cavity of the knee in rabbits, respectively. The changes of bone formation were examined and bone mineral density (BMD) was measured at 1, 3, 6, 12 and 16 weeks after surgery.

RESULTS AND CONCLUSION: There was some cartilage and bony forming in bFGF composite group than in the periostum wrapping tendon group at 3 weeks after operation, and reached normal bone hardness at 12 weeks. There was only hyaline degeneration and no bone formation in the control group. The bone mineral density of the periostum wrapping tendon group was greater than that of the other two groups (P < 0.01). These results demonstrated that the bFGF composite, under the induction of periosteum and bFGF factors, is of stronger bone-forming effects and can produce much cartilage and some bone in a short time. It can be used as the substitute for the lunate bone.

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