Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (11): 2000-2003.doi: 10.3969/j.issn.1673-8225.2010.11.025

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Effect of autumn and winter seasons on expression of surfactant associated protein A and interleukin-6 in healthy rat lung tissues

Lu Zhi-gang1, Wang Ya-li1,2, Zhang Ming-quan1, Guo Jin-qiao1, Shi Xu-liang1, Gao Yang1   

  1. 1School of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang  050017, Hebei Province, China;
    2Medical College, Hebei University of Engineering, Handan  056038, Hebei Province, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Wang Ya-li, Professor, Chief physician, Doctoral supervisor, School of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China; Medical College, Hebei University of Engineering, Handan 056038, Hebei Province, China wang1955@163.com
  • About author:Lu Zhi-gang, Studying for doctorate, School of Traditional Chinese Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China luzg7501@sina.com
  • Supported by:

    the National Traditional Chinese Medicine Administration Foundation of China, No. 06-07JP09*

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Abstract:

BACKGROUND: Previous study has confirmed that seasonal variation and surfactant associated protein A (SP-A) and interleukin-6 (IL-6) exhibit a significant role in lung immune and defense function. However, the effect mechanism of them remains unclear.
OBJECTIVE: By observing the changes of SP-A and IL-6 of male rats in autumn and winter, to explore the effects of seasonal changes on the nonspecific immunity of lung of normal rats, and to provide new ideas for the experimental basis to the cognition of pathology and physiology mechanism for seasonal attack of respiratory system diseases.
METHODS: Male SD rats were purchased from each seasons and divided into groups in chronological order. All rats were housed with normal forage and drank freely under room temperature. Then the rats were sacrificed by decapitation before 18 o’clock at corresponding solar term, and the lung tissues were analyzed by RT-PCR.
RESULTS AND CONCLUSION: Compared to the other groups, the expression of SP-A and IL-6 in the Winter Begins group were smaller, which demonstrated that immune function of lung was existed the seasonal rhythm of lower in winter and higher in autumn. The SP-A and IL-6 are main material basis of immune function.

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